Hi there. I'm a developmental biologist who went into genomics a few years ago. I had been trained tried-and-true assays: lots of in situ hybridizations and quite a bit of fate-mapping with fluorescent dextrans. I traded these approaches for molecular biology methods development, learning to properly do bioinformatics, and a complete revision of my thinking to intellectually accommodate billions of measurements.
Totally worth it. I never looked back.